These syndromes are characterized by a triad of Iris atrophy, Glaucoma, and Corneal decompensation.
Visual Acuity
Blurred Vision
Haloes around light
CONJUNCTIVA
Trabeculectomy Blebs +/- implant
CORNEA
Hammered Silver or Beaten Bronze appearance – Chandler syndrome.
Edema – due to sub-normal pump function by altered endothelial cells – may have micro-cysts in spite of having normal IOP.
IRIS AND PUPIL
Diffuse areas of Iris Atrophy
Correctopia
polycoria
Ectropion uvea
Peripheral Anterior Synechiae
Iris Nevus (Cogan-Reese Syndrome) – There is a diffuse nevus that coves the anterior iris. Iris pedunculated nodules may or may not be present, and the iris surface appears smudged.
LENS
Lenticular opacities
ANTERIOR CHAMBER AND ANGLE
Gonioscopy – Progressively angle closure in cases of essential iris atrophy
POSTERIOR SEGMENT
Signs of Glaucoma
IOP
Glaucoma
FELLOW EYE
Normal
ANCILLARY TESTING
Visual Fields
Specular Microscopy
OCT ONH
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